Section 06

The Science Library

Everything the rest of this site cites lives here: 39 peer-reviewed studies, official reports, and position papers. Each entry links out to the source and back to every article that uses it, so you can audit any claim in both directions.

How sources get in (and thrown out): see our citations and corrections policy. Want the skills to judge studies yourself? Read how to read a nutrition study without getting fooled.

Peer-reviewed studies

study

Reducing food's environmental impacts through producers and consumers

Poore, J. & Nemecek, T. (2018) · Science · DOI: 10.1126/science.aaq0216

A meta-analysis covering about 38,700 farms in 119 countries. The largest dataset comparing the environmental footprint of foods; the source of the finding that meat and dairy provide 18% of calories while using 83% of farmland.

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Carcinogenicity of consumption of red and processed meat

Bouvard, V., et al. (IARC Monograph Working Group) (2015) · The Lancet Oncology · DOI: 10.1016/S1470-2045(15)00444-1

The WHO cancer agency's classification of processed meat as a Group 1 carcinogen and red meat as Group 2A. The classification grades strength of evidence, not size of risk; the absolute risk increase is modest.

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A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults

Morton, R.W., et al. (2018) · British Journal of Sports Medicine · DOI: 10.1136/bjsports-2017-097608

A meta-analysis of 49 resistance-training trials (1,863 adults). Extra protein increased muscle and strength gains up to about 1.62 g/kg/day, beyond which no further benefit appeared, setting a practical ceiling for how much protein lifters need.

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High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores

Hevia-Larrain, V., et al. (2021) · Sports Medicine · DOI: 10.1007/s40279-021-01434-9

A 12-week trial: 19 habitual vegans (using soy protein) and 19 omnivores did matched resistance training at about 1.6 g/kg/day protein. Both gained the same muscle and strength, so an exclusively plant-based diet was not different from a mixed diet for building muscle when protein was matched.

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Delayed Onset Muscle Soreness Following Acute Resistance Exercise in Untrained Females: A Comparative Study Between Vegans and Omnivores

Njeim, P., et al. (2024) · International Journal of Sports Medicine · DOI: 10.1055/a-2350-8681

A comparison of 27 vegan and 27 omnivore untrained women after a resistance workout. The vegans were significantly less sore 48 hours later at several muscle sites and showed higher post-exercise grip strength. A small, single-session study, so suggestive rather than conclusive.

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Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study

Tucker, K.L., et al. (2000) · The American Journal of Clinical Nutrition · DOI: 10.1093/ajcn/71.2.514

In nearly 3,000 mostly meat-eating adults, about 39% had low-normal B12. Supplements and fortified cereal and milk protected B12 status; meat intake did not. Evidence that eating meat does not guarantee good B12 and that fortified foods and supplements are the reliable source.

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A cross-sectional study of nutritional status in healthy, young, physically-active German omnivores, vegetarians and vegans reveals adequate vitamin B12 status in supplemented vegans

Storz, M.A., et al. (2023) · Annals of Medicine · DOI: 10.1080/07853890.2023.2269969

Among healthy young Germans, vegans who supplemented B12 (about 90% of them, median 250 mcg/day) had B12 status comparable to omnivores, while lacto-ovo-vegetarians fared worse. Supplementing vegans match meat-eaters on B12.

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Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in US Adults

Satija, A., et al. (2017) · Journal of the American College of Cardiology · DOI: 10.1016/j.jacc.2017.05.047

Follows about 209,000 adults and finds plant-based diets built on whole foods are linked to lower coronary heart disease risk, while plant-based diets heavy in refined foods are not. Quality matters, not just the label.

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Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies

Schwingshackl, L., et al. (2017) · American Journal of Clinical Nutrition · DOI: 10.3945/ajcn.117.153148

Dose-response meta-analysis across food groups: higher intakes of whole grains, vegetables, fruit, nuts, and legumes track with lower all-cause mortality; higher red and processed meat intake tracks with higher mortality.

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Health effects of dietary risks in 195 countries, 1990–2017

GBD 2017 Diet Collaborators (Afshin, A., et al.) (2019) · The Lancet · DOI: 10.1016/S0140-6736(19)30041-8

The Global Burden of Disease analysis of diet and death worldwide. The biggest dietary killers it identifies are diets low in whole grains, fruits, nuts, and vegetables, alongside high sodium.

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Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians over 18 years of follow-up: results from the prospective EPIC-Oxford study

Tong, T. Y. N., et al. (2019) · BMJ · DOI: 10.1136/bmj.l4897

EPIC-Oxford cohort of about 48,000 people: vegetarians and vegans had lower ischaemic heart disease risk than meat eaters, alongside a smaller increase in haemorrhagic stroke. An honest picture with findings in both directions.

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Carbohydrate quality and human health: a series of systematic reviews and meta-analyses

Reynolds, A., et al. (2019) · The Lancet · DOI: 10.1016/S0140-6736(18)31809-9

Commissioned by the WHO: people eating the most fiber (mostly from whole plant foods) had 15 to 30% lower all-cause mortality and lower incidence of heart disease, stroke, type 2 diabetes, and colorectal cancer.

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Soy intake is associated with lowering blood pressure in adults: A systematic review and meta-analysis of randomized double-blind placebo-controlled trials

Mosallanezhad, Z., et al. (2021) · Complementary Therapies in Medicine · DOI: 10.1016/j.ctim.2021.102692

Pooled 17 randomized double-blind placebo-controlled trials. Soy intake lowered systolic blood pressure by about 1.7 mmHg and diastolic by about 1.3 mmHg on average, with larger effects in younger adults.

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A Meta-Analysis of 46 Studies Identified by the FDA Demonstrates that Soy Protein Decreases Circulating LDL and Total Cholesterol Concentrations in Adults

Blanco Mejia, S., Messina, M., Li, S. S., et al. (2019) · The Journal of Nutrition · DOI: 10.1093/jn/nxz020

Re-analyzed the 46 trials the FDA used to weigh its soy heart-health claim. A median 25 g of soy protein a day lowered LDL, the harmful cholesterol, by about 3 to 4%, the basis for the claim that soy protein may reduce heart-disease risk.

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Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies

Reed, K. E., Camargo, J., Hamilton-Reeves, J., Kurzer, M. & Messina, M. (2021) · Reproductive Toxicology · DOI: 10.1016/j.reprotox.2020.12.019

Pooled 41 clinical studies covering more than 1,700 men and found that neither soy foods nor isoflavones changed testosterone or estrogen levels at any dose. The clearest evidence against the myth that soy feminizes men.

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Soy and isoflavones consumption and breast cancer survival and recurrence: a systematic review and meta-analysis

Qiu, S. & Jiang, C. (2019) · European Journal of Nutrition · DOI: 10.1007/s00394-018-1853-4

Across 12 studies of more than 37,000 women with breast cancer, soy and isoflavone intake was not harmful and was associated with lower recurrence, with a small survival benefit for pre-diagnosis intake. Supports that soy is safe for breast-cancer survivors.

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Effects of cow's milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study

He, M., Sun, J., Jiang, Z. Q. & Yang, Y. X. (2017) · Nutrition Journal · DOI: 10.1186/s12937-017-0275-0

A randomized crossover trial in 600 adults with milk intolerance. Milk with only A2 beta-casein caused significantly less bloating, pain, and loose stool than ordinary A1/A2 milk, and the benefit held even in people who could digest lactose, pointing to dairy protein, not just lactose, as a trigger.

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Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., et al. (2014) · Nature · DOI: 10.1038/nature12820

Switching to an animal-based diet changed the gut bacteria within a single day: it increased bile-tolerant microbes including Bilophila wadsworthia, which is linked to inflammation and inflammatory bowel disease, and reduced the Firmicutes that ferment plant fiber. A plant-based diet shifted the community the other way.

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Potential renal acid load of foods and its influence on urine pH

Remer, T. & Manz, F. (1995) · Journal of the American Dietetic Association · DOI: 10.1016/S0002-8223(95)00219-7

The original potential renal acid load (PRAL) framework. Protein-rich animal foods like meat, fish, hard cheese, and eggs are acid-forming in the body, while fruits and vegetables are alkaline-forming. The basis for the idea that an animal-heavy diet raises the body's dietary acid load.

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Perceptions of flatulence from bean consumption among adults in 3 feeding studies

Winham, D. M. & Hutchins, A. M. (2011) · Nutrition Journal · DOI: 10.1186/1475-2891-10-128

About half of people starting a daily serving of beans reported more gas in the first week, but it was temporary: 70% or more of those who noticed it felt it fade by the second or third week as their gut adjusted. Evidence that fiber bloat is an adjustment phase, not a permanent verdict.

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The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis

Moayyedi, P., Quigley, E. M. M., Lacy, B. E., et al. (2014) · American Journal of Gastroenterology · DOI: 10.1038/ajg.2014.195

Pooled 14 trials in 906 people with IBS. Fiber helped overall, but the benefit was limited to soluble fiber such as psyllium; insoluble wheat bran did not help and can worsen bloating. The reason the type of fiber matters when you start adding more plants.

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A diet low in FODMAPs reduces symptoms of irritable bowel syndrome

Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R. & Muir, J. G. (2014) · Gastroenterology · DOI: 10.1053/j.gastro.2013.09.046

A randomized crossover trial in 30 people with IBS. Cutting fermentable carbs (FODMAPs) roughly halved gut-symptom scores compared with a typical diet. The evidence base for using a low-FODMAP elimination-and-reintroduction approach to isolate which foods are triggering symptoms.

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Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach

Kaltenbach, T., Crockett, S. & Gerson, L. B. (2006) · Archives of Internal Medicine · DOI: 10.1001/archinte.166.9.965

A systematic review of reflux lifestyle advice. Weight loss, raising the head of the bed, and leaving 2 to 3 hours between the last meal and lying down had real supporting evidence. Common trigger foods like chocolate, coffee, and fat relax the esophageal valve in lab studies, but the proof that avoiding them improves symptoms is weaker.

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A comparison of alkaline water and Mediterranean diet vs proton pump inhibition for treatment of laryngopharyngeal reflux

Zalvan, C. H., Hu, S., Greenberg, B. & Geliebter, J. (2017) · JAMA Otolaryngology–Head & Neck Surgery · DOI: 10.1001/jamaoto.2017.1454

In 184 people with throat-reflux symptoms, a 90 to 95% plant-based Mediterranean diet with alkaline water matched proton pump inhibitor drugs: 62.6% improved on the diet versus 54.1% on the medication. Among the strongest evidence that a plant-forward diet can rival reflux medication.

Reports, position papers & preprints

preprint

Making AI Less "Thirsty": Uncovering and Addressing the Secret Water Footprint of AI Models

Li, P., Yang, J., Islam, M. A. & Ren, S. (2023) · arXiv (preprint)

The most-cited estimate of AI water use. Its abstract reports that training GPT-3 in US data centers directly evaporated about 700,000 litres of freshwater; the paper also estimates roughly 500 ml consumed per 10 to 50 medium-length responses. A preprint, so treat the numbers as estimates; we use it because public AI water data is scarce.

position

Position of the Academy of Nutrition and Dietetics: Vegetarian Diets

Melina, V., Craig, W. & Levin, S. (2016) · Journal of the Academy of Nutrition and Dietetics · DOI: 10.1016/j.jand.2016.09.025

The largest US dietetics body's position: appropriately planned vegetarian and vegan diets are healthful, nutritionally adequate, and appropriate for all life stages, including pregnancy, infancy, and athletes.

Official reference pages

reference

FSIS Guideline on Substantiating Animal-Raising or Environment-Related Labeling Claims

USDA Food Safety and Inspection Service (2024) · USDA FSIS Guideline 2024-0006

The US government's own guideline for how claims like "free range" and "humanely raised" get onto packages: companies substantiate them with paperwork submitted to USDA, not through on-farm inspections. Reading it is the fastest way to see how little most labels guarantee.

reference

Lactose intolerance

MedlinePlus Genetics, National Library of Medicine (2024) · National Institutes of Health

The NIH reference on lactose intolerance: about 65% of people worldwide lose much of their ability to digest lactose after infancy, from roughly 5% of people of Northern European descent to 70 to 100% in East Asian populations.